Witamina D oraz Izotretinoina inhibituje wzrost GBM >50%
Effects of vitamin D and retinoic acid on human glioblastoma cell lines
przedruk z:
http://www.springerlink.com/content/q316j49523x4x673/
L. Magrassi1, 2, G. Butti1 Contact Information, S. Pezzotta1, L. Infuso1 and G. Milanesi2
(1) Department of Surgery, Section of Neurosurgery, University of Pavia, IRCCS Policlinico S. Matteo, Pavia, Italy
(2) IGBE CNR, Pavia, Italy
Summary
The biological significance of vitamin D receptors expressed by glioblastoma and other glial tumours is still unclear. In an effort to clarify this issue we studied the effects of increasing concentrations of 25-dihydroxyvitamin D3 and its metabolite 1 agr, 25-dihydroxyvitamin D3 on two human glioblastoma cell lines. Both substances were capable of inducing a significant (> 50%) reduction in growth of the two glioblastoma cell lines at dosages over 5 mgrM. When the HU 70 cell line was treated by increasing dilutions of 25-dihydroxyvitamin D3 combined with 1 mgrM all trans-retinoic acid, significant inhibition was apparent even after addition of 25-dihydroxyvitamin D3 in the nanomolar range. Reduction of growth index was mainly due to induced cell death.
Our results providein vitro evidence that vitamin D metabolites alone or in combination with retinoids may be potentially useful agents in the differentiation therapy of human malignant gliomas.