Tutaj ciekawe info o TLS i symtomach oraz zapobieganiu:
Recognising and managing TLS ( Tumour Lysis Syndrome )risk factors is critical to DCA treatment and other Cancer treatments.
Current Cancer protocols recognise some but not all TLS risk factors . Consequently rapid onset TLS can result in dire consequences.
It is recognised that TLS can occur spontaneously within days of chemotherapy. To date it has been accepted that those most at risk are :-
1. Those having large tumour burdens.
2.Those with cancer having high sentsitivity to the Chemotherapy agent which results in a rapid kill of cancer cells.eg.g. Leukemias, Small cell cancers, high grade Lymphomas, multiple small cancer tumours.
3. Patients with pre-existing Renal problems.
4. Pre-existing Hyperkalemia ( Abnormal high Potassium) and Hypocalaemia.( abnormal low Calcium )
Unfortunately many Cancer patients have subclinical Hyperkalemia and Hypocalcaemia due to prolonged subclinical acidosis which is not so obvious from blood acidity analyses but is obvious from consistently high acid levels in Saliva and urine.
When a TLS event occurs where there are already higher than normal levels of Potassium and diminished levels of Calcium in extracellular fluids , the sudden release of additional potassium and futher loss of Calcium due to Calcium Phosphate precipitation results in a rapid serious TLS situation.
kiedy ma miejsce TLS, poziomy potasu juz sa za wysokie. Niskie sa takze poziomy Calcium obecnego w plynach pozakomurkowych. Dodatkowe, nagle uwalnianie potasu i dalsze obnizanie Calcium oraz co za tym idzie wytracaniem sie fosforanow, moze spowodowac bardza nagla i powazna sytacje TLS.
In patients with normal Potassium and Calcium levels there is a better capacity to cope with a TLS event.
Pacjenci , ktorzy maja normalny poziom potasu i Calcium, potrafia znacnie lepiej kompensowac objawy TLS.
THE MESSAGE ONCE AGAIN IS TO CONTROL BODY FLUID ACIDITY AND KEEP SALIVA pH 6.8+ and URINE 7.0+ TO REDUCE THE RISK OF TLS MINOR AND MAJOR CONSEQUENCES.
A WIEC RAZ JESZCZE, w CELU ZMNIEJSZENIA RYZYKA TLS, ORAZ MNIEJSZYWCH BADZ WIEKSZYCH KONSEKWENCJI TEGOZ SYNDROMU, WAZNYM JEST ABY KONTROLOWAC KWASOWOSC PLYNOW I MAJAC NA UWADZE TO ABY pH SLINY BYLO W GRANICACH[color=red] 6.8+, A MOCZU 7.0+.[/color]
In the "CDA + Antioxidant draft protocol" 10 gms per day of Ascorbate ( not mega doses) is suggested, preferably as the Calcium Ascorbate salt. This is in addition to an alkaline diet+ supplements to raise pH levels of Saliva to 6.8+ and Urine to 7.0+.
Without checking your pH levels regularly ( Twice Daily )you will have no idea what your pH levels and daily fluctuations might be.
If you were a diabetic would you not check your blood glucose levels regularly regardless of diet ???
Other factors can still affect pH levels including Chemotherapy, Radiation,TLS, Exercise, Stress, Tumour Lactic acid production etc. That is why regular pH checking is so important.
IS REGULAR pH TESTING INCONVENIENT ?...........YES
IS IT ABSOLUTELY CRITICAL?......................YES
********* CANCER IS ALSO VERY INCONVENIENT AND **************
******** THE TREATMENT PROTOCOL BECOMES VERY CRITICAL. ********
I have been looking at the chemistry of Tumour Lysis.
The literature particularly notes release of Uric acid, calcium and phosphate as Cancer cells breakdown. I am sure that there are other breakdown products which are not as well documented.
Firstly considering Uric Acid it has greatly reduced solubility if the body fluids particularly urine is acidic pH below 6.5 for example.The precipitation noccurs in the Kidneys causing restricted filtration and build up of excessive salts such as calcium in the body which would normally be excreted through the urine.
This Uric acid blockage is normally corrected by making the urine more alkaline. In a hospital situation this might be by infusion of sodium bicarbonate.
On the other hand if the patient urine is too alkaline say pH over 6.8 Calcium Phosphate can precitate in the urine and could lead to excessive Calcium losses unless dietary Calcium exceed the loss due to the Phosphate precipitation of the calcium. If the calcium is very much in excess Calcium Phosphate salts can precipitate at lower pH levels that 6.8 and create Hypo-Phosphate levels.
The Hypercalcium condition described at first pass may be due to an excessive body fluid acidity which has resulted in Uric acid precipitation in the kidneys. Check Saliva and Urine pH levels and if lower than 6.8 this can be corrected.
Adjusting the Urine pH levels to 7.0 may solve all these problems.
Do you have any other Blood test results to share which also indicate kidney / renal problems.
Keep us briefed and we will try and work through this together.
Please ensure that after week 4 that you are not showing symptoms of TLS due to cancer cell death. This creates HyperKalemia( High Potassium ) and HypoCalcaemia (Low Calcium ) and uric acid release into your system which can cause partial kidney blockage with Calcium Urate crystals. If this is the case stop taking the DCA for a week, drink plenty of water vand fluid to keep your kidneys well flushed , take additional calcium supplements and consult your doctor for further TLS advice.
If you are sure that this is not the case and your current DCA protocol is not working this may be due to excess acidity build up by week 4 .
Please check and monitor twice a day the pH of your Saliva and Urine using a pH meter. Adopt an Alkaline foods diet and supplements to reduce your acidity .e.g. Dolomite ( Calcium-Magnesium Carbonate), Milk of Magnesia.
Your pH levels should be Saliva pH 6.8 or higher and Urine 7.0 or higher. Many cancer patients have pH levels as low as 5.0 which means 100 times the acidity of the ideal normal level. Acidity encourages the spread of cancer.
You may also have sub-clinical acidosis which results in sub-clinical hyperkalemia ( High Potassium ) and Hypocalcaemia ( low Calcium )
Also take at least 10 grams daily of Calcium ascorbate which can function as a pro oxidant in cancer cells under the correct pH conditions. R-Lipoic acid 500mg daily also has been suggested as another antioxidant to be taken with DCA.
Once you have checked this get back as depending upon your findings and other symptoms your current diet, supplements and protocols may require further adjustment.
wiecej o TLS: